Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3)

What is Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3)?

Progressive Retinal Atrophy, Rod-Cone Dysplasia 3 is an inherited eye disease affecting dogs. PRA-rcd3 is an early onset disease that affects cells that transmit visual information in the retina. This disease progressively results in loss of vision.

Starting around 4 weeks of age affected dogs have abnormal thinning and degeneration of the retina. Signs of progressive retinal atrophy including changes in reflectivity and appearance of a structure behind the retina called Tapetum.

Early signs will be a loss of peripheral vision and night vision. As the disease progresses additional cells degenerate resulting in complete blindness. Most affected dogs are blind by 1 year of age. Others may retain limited sight until around 3 or 4 years of age.

What Causes Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3)?

Pembroke Welsh Corgis along with other dog breeds are susceptible to this disease. PRA-RCD3 is an inherited disease resulting from 2 mutated PDE6A genes, 1 from each parent. If the corgi's parents both passed on a mutated PDE6A gene then the corgi will be at risk for the disease.

Two inherited mutations of the PRA-RCD3 gene associated with Progressive Retinal Atrophy Rod-cone Dysplasia 3 from the corgi's parents will put your dog At Risk for PRA-RCD3.

There are 3 test results for PRA-RCD3:

Clear - A (Normal)

Carrier - B (Carrier)

At Risk - C (At Risk)

If your corgi is Normal or a Carrier then your dog should not be at risk to suffer from this specific genetic disease as both genetic mutations must be passed on for your dog to have PRA-RCD3.

There may be other causes of this condition in corgis. A normal result does not exclude a similar genetic disease.

How is Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3) Diagnosed?

Genetic testing of the corgi for a pair of mutated PDE6A genes and or an eye exam from a veterinarian. The eye exam should be done around 6 to 16 weeks of age for observable irregularities to appear.

Breeding out Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3)

As breeders and corgi owners it's our responsibility to genetically test for diseases that affect Pembroke Welsh Corgis. Not only to loosen the grip that Progressive Retinal Atrophy Rod-cone Dysplasia 3 has on the breed, but to improve genetic diversity.

There are multiple genetic factors to consider when breeding. We cannot simply test and breed solely on PRA-RCD3 status. We must not pigeon-hole the genetic makeup of the breed. In doing so we will do more harm than good.

Getting a corgi from a responsible breeder will improve you and your corgi's chances of never experiencing a preventable disease.

What Can You Do?

Find a breeder who tests their corgis for diseases like Progressive Retinal Atrophy Rod-cone Dysplasia 3 (PRA-RCD3), ask what other testing is being done, ask them to see the test results. You must advocate for your future puppy.

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